Hypolipidaemic and anti-lipidperoxidant activities of Ganoderma lucidum polysaccharide (2018)


International Journal of Biological Macromolecules Volume 118, Part B, 15



Ganoderma lucidum polysaccharide (GLP) was prepared by hot water extraction and partly characterised by high-performance gel filtration chromatography and its monosaccharide composition. Male Sprague–Dawley rats were randomly divided into four groups: one group received a high-fat diet (control group) and the three other groups received a high-fat diet containing 100, 300 and 500 mg/kg of GLP. GLP administration reduced the body weight gain, food efficiency ratio, levels of plasma triacylglycerol (TG), plasma total cholesterol (TC) and low-density lipoprotein cholesterol and liver weight, TC and TG levels and malondialdehyde values, improved the levels of faecal fat, cholesterol and plasma high-density lipoprotein cholesterol and enhanced the activities of serum superoxide dismutase and glutathione peroxidase in rats compared with the control group. The appropriate dose of GLP was 300 mg/kg. Results indicate that GLP exhibits hypolipidaemic and lipid antioxidant activities and may be used as a drug for hyperlipidaemia treatment.


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