Protein‐Bound β‐glucan from Coriolus Versicolor has Potential for Use Against Obesity
The prevalence of obesity and related disorders has vastly increased throughout the world and prevention of such circumstances thus represents a major challenge. Here, it has been shown that one protein‐bound β‐glucan (PBG) from the edible mushroom Coriolus versicolor can be a potent anti‐obesity component.
Methods and results
PBG can reduce obesity and metabolic inflammation in mice fed with a high‐fat diet (HFD). Gut microbiota analysis reveals that PBG markedly increases the abundance of Akkermansia muciniphila, although it does not rescue HFD‐induced change in the Firmicutes to Bacteroidetes ratio. It appears that PBG alters host physiology and creates an intestinal microenvironment favorable for A. muciniphila colonization. Fecal transplants from PBG‐treated animals in part reduce obesity in recipient HFD‐fed mice. Further, PBG is shown to upregulate expression of a set of genes related to host metabolism in microbiota‐depleted mice.
The data highlight that PBG may exert its anti‐obesity effects through a mirobiota‐dependent (richness of specific microbiota) and ‐independent (modulation of host metabolism) manner. The fact that C. versicolor PBGs are approved oral immune boosters in cancers and chronic hepatitis with well‐established safety profiles may accelerate PBG as a novel use for obesity treatment.
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